NHK World的「醫學前沿」生物製劑對發炎性疾病的影響 (The Impact of Biologics on Inflammatory Diseases )節目 ：關於 生物製劑 ( biologics，主要由抗體製成)，徹底改變了哮喘(和類風濕性關節炎等)慢性發炎性疾病的治療方法…

 

NHK新聞

https://www3.nhk.or.jp › ... › 影片 › 醫學前沿

生物製劑主要由抗體製成，徹底改變了哮喘和類風濕性關節炎等慢性發炎性疾病的治療方法…

人工智慧概述

NHK的《醫學前沿》（以及相關的NHK World內容）涵蓋了關節炎研究，重點關註生物製劑等革命性療法在炎症性關節炎（RA）治療中的應用，著重介紹其靶向炎症和促進癒合的能力，並探索諸如磁引導幹細胞療法修復軟骨等創新技術，以及骨關節炎（OA）的實用策略，包括體重管理、治療和先進運動修復軟骨的尖端

NHK關節炎專題報導重點：

類風濕性關節炎（RA）的生物製劑：

展示了基於抗體的藥物（生物製劑）如何阻斷發炎物質，從而改變RA的治療方式，並舉例說明了患者骨骼再生的案例。

重點介紹了先進的生物製劑給藥系統，例如皮下注射器，提高了患者的便利性。

幹細胞療法與軟骨修復：

重點介紹了利用磁力靶向鐵標記幹細胞來精確修復受損膝關節軟骨的方法，這是一種比手術創傷更小的替代方案。

示範如何利用磁鐵引導這些細胞到達缺損區域，從而促進自然修復。

骨關節炎（OA）的管理：

強調維持健康體重、肌力訓練和伸展運動對於延緩OA進展的重要性，因為磨損的軟骨無法自然再生。

涵蓋了先進的髖關節置換手術，顯示了人工關節如何幫助重症患者恢復活動能力和生活品質。

了解自體免疫：

本節目將探討類風濕性關節炎等自體免疫疾病的潛在免疫系統功能障礙，即人體攻擊自身組織。節目中也將介紹坂口志門等諾貝爾獎得主的見解。

更多資訊：

請關注NHK World的「醫學前沿」節目或相關健康節目，以獲取關於這些主題的詳細專題報導。

NHK xīnwén

https://Www3.Nhk.Or.Jp›... › Yǐngpiàn› yīxué qiányán





NHKニュース
https://www3.nhk.or.jp › ... › Video › Medical Frontiers

Biologic drugs, made mainly from antibodies, have transformed the approach to treating chronic inflammatory diseases such as asthma and rheumatoid arthritis ...

AI Overview

+6

NHK's "Medical Frontiers" (and related NHK World content) 

covers arthritis research focusing on revolutionary treatments like biologics for inflammatory arthritis (RA), highlighting their ability to target inflammation and promote healing, and exploring innovations like magnetic guidance for stem cell therapy to repair cartilage, alongside practical management strategies for osteoarthritis (OA) focusing on weight, exercise, and advanced hip replacements, showcasing Japan's cutting-edge approaches to arthritis care. 

Key Themes in NHK's Arthritis Coverage:

• Biologics for Rheumatoid Arthritis (RA):
  • Shows how antibody-based drugs (biologics) block inflammation-causing substances, transforming treatment for RA, with examples of bone regeneration in patients.
  • Highlights advanced delivery systems for biologics, like subcutaneous injectors, improving patient convenience.
• Stem Cell Therapies & Cartilage Repair:
  • Features magnetic targeting of iron-labeled stem cells to precisely repair damaged knee cartilage, a less invasive alternative to surgery.
  • Demonstrates how these cells can be guided to defect areas using magnets, promoting natural repair.
• Osteoarthritis (OA) Management:
  • Emphasizes maintaining a healthy weight, strength training, and stretching to slow OA progression, as worn cartilage doesn't regenerate naturally.
  • Covers advanced hip replacement surgeries, showing how artificial joints restore mobility and quality of life for severe cases.
• Understanding Autoimmunity:
  • Explores the underlying immune system dysfunction in autoimmune diseases like RA, where the body attacks itself, with insights from Nobel Laureates like Sakaguchi Shimon. 

Where to Find More:

• Look for episodes or segments on NHK World's "Medical Frontiers" or related health programs for detailed features on these topics. 

人工智慧概述

生物製劑和生物相似藥：科學及其應用綜述…

生物製劑是由活體生物（如細胞、組織或微生物）或其產物（如蛋白質、抗體、基因）製成或衍生的複雜藥物，用於透過模擬體內天然物質來預防或治療疾病，這與結構更簡單的化學合成藥物不同。它們是大型、複雜的分子，需要先進的生物技術才能生產，包括疫苗、血液製品、荷爾蒙（如胰島素）和細胞/基因療法，通常用於治療自體免疫疾病、癌症和遺傳性疾病等複雜疾病。

主要特徵：

來源：來自活體生物（人類、動物、微生物）。

複雜性：大型、複雜的分子（醣類、蛋白質、核酸），與結構較簡單的合成藥物不同。

生產：利用生物技術在活細胞系統中生產，需要精確控制。

例如：疫苗、抗體、荷爾蒙、胰島素、血液成分、基因療法、細胞療法和重組蛋白。

與傳統藥物的區別：

生產：化學合成藥物的結構已知，而生物製劑是來自生物系統的複雜混合物，因此更難進行表徵。

敏感性：生物製劑通常對熱敏感且易受污染，需要在無菌生產條件下進行。

標靶性：其複雜性使其能夠與複雜的生物標靶相互作用，例如免疫細胞或特定蛋白質。

治療範圍：

自體免疫疾病（例如類風濕性關節炎）

癌症

遺傳性疾病

傳染病（疫苗）

AI Overview

Biologics are complex medicines made from or derived from living organisms (like cells, tissues, or microorganisms) or their products (like proteins, antibodies, genes), used to prevent or treat diseases by mimicking natural substances in the body, unlike simpler, chemically synthesized drugs. They are large, intricate molecules, requiring advanced biotechnology for production, and include vaccines, blood products, hormones (like insulin), and cell/gene therapies, often treating complex conditions such as autoimmune disorders, cancer, and genetic diseases. 

Key Characteristics:

• Source: Come from living sources (human, animal, microbial).
• Complexity: Large, complex molecules (sugars, proteins, nucleic acids) unlike simpler, synthetic drugs.
• Production: Made using biotechnology in living cell systems, requiring precise control.
• Examples: Vaccines, antibodies, hormones, insulin, blood components, gene therapies, cell therapies, and recombinant proteins. 

How They Differ from Traditional Drugs:

• Manufacturing: Chemically synthesized drugs have known structures, whereas biologics are complex mixtures from living systems, making them harder to characterize.
• Sensitivity: Biologics are often heat-sensitive and susceptible to contamination, needing sterile production conditions.
• Targeting: Their complexity allows them to interact with intricate biological targets, like immune cells or specific proteins. 

What They Treat:

• Autoimmune diseases (e.g., rheumatoid arthritis)
• Cancers
• Genetic disorders
• Infectious diseases (vaccines)