馬修擁有美國及加拿大雙重國籍。他於1995年曾經與亞斯敏·布萊斯交往，於1995至96年間與茱莉亞·羅勃茲關係密切，並於2006至2012年間與麗茲·凱普蘭有過一段比較長的感情[16][17][18]。
他自稱14歲已經開始酗酒[19]。於1997年一次水上機車意外後對止痛藥成癮，並於當年經歷了為期28天的戒毒療程[20]。體重一度跌至僅餘58公斤，每天服用多達55顆維柯丁[21][22]。30歲時曾因為酒精誘發的胰腺炎入院[20][23] 。在一次嚴重宿醉後，派瑞曾於2002年發誓不再於《六人行》片場內喝酒，然而於接下來的季度中他仍經常被發現於片場喝醉[11]。同劇的演員都曾嘗試過幫協助其戒酒，但均無明顯改善[19]。
2023年10月28日，洛杉磯警員發現派瑞在家中的熱水浴缸內疑似溺水身亡，享年54歲。[24][25]
2024年5月，洛杉磯警察局對導致馬修·派瑞死亡的過量K粉來源展開調查[26]。同年8月15日，警方正式起訴五名涉案人員，稱五人涉嫌分銷導致派瑞及另一人死亡的K粉，分別為派瑞的私人助理、兩名醫生和兩名毒販（包括電視劇導演埃里克·弗萊明）[27][28][29][30]，其中三人已認罪。美國檢察官馬丁·埃斯特拉達（Martin Estrada）表示，派瑞去世前兩個月曾以5.5萬美元現金從兩名醫生那裡購買K粉[31]。
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https://en.wikipedia.org/wiki/Matthew_Perry
Perry, Matthew (November 1, 2022). Friends, Lovers, and the Big Terrible Thing: A Memoir. Foreword: Lisa Kudrow. New York: Flatiron Books
王璞《老友記、大情人和大麻煩》
這是馬修·派瑞（Matthew Perry)回憶錄的書名。你也許不知馬修·派瑞何許人也，但一說美國電視連續劇《老友記》中的錢德勒，九零後以前的人大抵都熟悉吧？從1994年到2004年，整整十年的時間裏，似乎全世界都在瘋狂追看那套電視劇。馬修就是錢德勒的扮演者，那六名老友中最搞笑最可愛的一位。
我追看這部劇時它已經播完，我是買磁碟來看的。那時我剛從大學辭職回家，想要強化自己的英文聽力，幾位朋友就不約而同向我推薦這套劇，說是把它從頭到尾看一遍，聽力一定大大進步。結果我把它至少看了五遍，10季234集乘以五呀！因為作為英語聽說訓練教材，它太完美了，基本上都是日常生活用語，演員們發音字正腔圓。最主要的是，它好看，百看不厭。
整整一代青少年在這部劇的伴隨下成長，而那六朋友扮演者的命運，也因這部劇而改變。他們接拍這部劇時都是無名演員，年輕，錢包羞澀。第一季第一集播放之前，製片人用專機把他們送到拉斯維加斯，給他們一人兌換一百美元籌碼，說：「這部劇將會徹底改變你們的人生，這是你們作為普通人在公眾場所盡情玩樂的最後一夜了。」
果不期然，劇集播放後六位主演一夜成名，財源廣進，名滿天下，無論出現在哪裏都引起轟動。這曾是他們夢寐以求的熱望，尤其是馬修·派瑞。出演《老友記》前他銀行賬戶上只剩三十美金，住在一間租來的公寓房子，已經有酗酒嗑藥的苗頭。他想成名想得都快瘋了。一心以為成名能解決自己的所有問題。「上帝呀！」有一天，他跪下來祈禱，「你要對我作甚麼都行，只要能讓我成名。」
三星期後，他祈禱的後半部應驗了，他接到了錢德勒這個角色，一舉成名。片約滾滾而來，片酬突飛猛進，儼然大演員、大富豪、大情人。可他的問題都解決了嗎？讀完這本書你就知道答案了。如果說大多回憶錄都是講述怎樣把一手爛牌打成大滿貫，那麼這本回憶錄講的卻是：怎樣把一手好牌輸得精光。
我覺得對大多數讀者來說，它反而比那些勵志回憶錄更有教益，它讓我們知道，名利雙收并非總是好事。醜小鴨變天鵝之後并非都「從此過上了幸福的生活」。成名跟成功之間不是總能夠劃上等號，而財富也絕非快樂的同義詞。
這本書出版一年後，馬修·派瑞就真的死於吸毒。其實他是六朋友中最為得天獨厚的：出身富家，父母皆名人，自身才華橫溢得驚人，也并不缺少機遇，情場上更所向披靡，在他長長的情人名單中，甚至有羅拔絲·朱麗婭這樣的巨星。然而，他卻在五十三歲的盛年孤獨地死在自己的超級豪宅。此書成了他留給世人的警世通言。
David Hubel, Nobel-Winning Scientist, Dies at 87
By DENISE GELLENE
Published: September 24, 2013
Dr. David Hubel, who was half of an enduring scientific team that won a Nobel Prize
for explaining how the brain assembles information from the eye’s
retina to produce detailed visual images of the world, died on Sunday in
Lincoln, Mass. He was 87.
Associated Press
Dr. David Hubel, right, celebrating with his longtime
collaborator, Dr. Torsten Wiesel, after they won the Nobel Prize in
1981.
The cause was kidney failure, his son Carl said.
Dr. Hubel (pronounced HUGH-bull) and his collaborator, Dr. Torsten Wiesel,
shared the 1981 Nobel in Physiology or Medicine with Roger Sperry for
discovering ways that the brain processes information. Dr. Hubel and Dr.
Wiesel concentrated on visual perception, initially experimenting on
cats; Dr. Sperry described the functions of the brain’s left and right
hemispheres.
Dr. Hubel’s and Dr. Wiesel’s work further showed that sensory
deprivation early in life can permanently alter the brain’s ability to
process images. Their findings led to a better understanding of how to
treat certain visual birth defects.
Dr. Hubel and Dr. Wiesel collaborated for more than two decades,
becoming, as they made their discoveries, one of the best-known
partnerships in science.
“Their names became such a brand name that H&W rolled off the tongue
as easily in the lab as A&W root beer did at lunch,” Robert H.
Wurtz, a neuroscientist, wrote in a review article about their work.
Before Dr. Hubel and Dr. Wiesel started their research in the 1950s,
scientists had long believed that the brain functioned like a movie
screen — projecting images exactly as they were received from the eye.
Dr. Hubel and Dr. Wiesel showed that the brain behaves more like a
microprocessor, deconstructing and then reassembling details of an image
to create a visual scene.
By measuring the electrical impulses of cells in the visual cortex, the
scientists discovered that cells respond to straight lines, movement and
contrast — features that delineate objects in the environment. They
further found that some cells fire rapidly in response to horizontal
lines, while other cells prefer vertical lines or angles. Cells with
similar functions are organized into columns, they said, tiny
computational machines that relay information to a higher region of the
brain, where a visual image is formed.
Dr. Hubel and Dr. Wiesel also found that vision does not develop
normally if the brain fails to make connections with the eye during a
critical window early in life.
In a 1962 experiment, the scientists showed that kittens that had one
eye sewn shut after birth became blind in that eye because their brains
were deprived of visual stimulation. In a related experiment, the
scientists showed that exposure to light did not by itself provide
enough stimulation; it was necessary for newborn animals to see the
patterns and contours of the world around them.
Doctors now operate on infants born with cataracts early in life to
prevent vision loss; before Dr. Hubel’s and Dr. Wiesel’s research,
doctors removed cataracts from infants between ages 6 months and 24
months, with poor results. The research also led to earlier treatment
for strabismus, a condition in which the eyes are not properly aligned.
Scientists have since found evidence of similar “critical periods” in hearing and language acquisition.
“David and Torsten did more than open up the study of the primary visual
cortex; they laid the basis of all that was to follow in the sensory
systems,” Dr. Eric R. Kandel, a Nobel laureate, wrote in a recent
commentary about their research. “Together this body of work stands as
one of the great biological achievements of the 20th century.”
David Hunter Hubel was born in Windsor, Ontario, on Feb. 27, 1926, to
American parents. His father was a chemical engineer. Dr. Hubel grew up
in Montreal, where his boyhood hobbies included chemistry. He once
rocked his neighborhood by firing a small cannon in the middle of his
street; in another experiment, he launched a hydrogen balloon that was
found by a farmer’s daughter 100 miles away.
He went to McGill University, where he studied math and physics because
he preferred solving problems to memorizing facts. But after earning his
bachelor’s degree in 1947, he decided against a career in mathematics.
“To make it in that field required a virtuosity — like becoming a
concert pianist — that I probably lacked,” he told an interviewer.
Thinking he might like to do medical research, he went on to medical
school at McGill and soon found himself straining to remember every
muscle in the body. But he got to spend summers at Montreal Neurological
Institute, where he became fascinated with the nervous system.
After receiving his medical degree in 1951, he studied neurology at
McGill for three years before heading to Johns Hopkins University in
Baltimore for a neurology fellowship. The Korean War interrupted his
plans.
He was drafted into the United States Army and assigned to the
neuropsychiatry division at Walter Reed Army Institute of Medical
Research, where his efforts soon turned to the visual system. He
developed an implantable tungsten electrode and a method for using it to
measure the firing of brain cells in cats as they watched a moving spot
on a screen. He found that cells were very selective; they fired when
the spot moved in one direction but not another. Some cells did not fire
at all.
Dr. Hubel’s Army service ended in 1958, but he could not immediately
resume his Johns Hopkins fellowship because the laboratory that had
recruited him was being remodeled. Another Johns Hopkins neurologist,
Dr. Stephen Kuffler, impressed with Dr. Hubel’s work at Walter Reed,
invited him to spend a year in his lab. Dr. Kuffler paired Dr. Hubel
with another young scientist interested in vision, Dr. Wiesel.
In 1959, the scientists were recruited with their mentor to Harvard
Medical School, where Dr. Hubel spent the rest of his career. He
maintained his lab well past his official retirement, and until January
taught a freshman seminar, in which students learned to use soldering
irons to build biomedical instruments, and received training in surgical
techniques.
His wife, Ruth, died in February. In addition to his son Carl, Dr.
Hubel’s survivors include two other sons, Eric and Paul, and four
grandchildren.
Dr. Hubel and Dr. Wiesel liked to recall that their initial discovery
about how vision works resulted from luck. Working in a tiny basement
laboratory at Johns Hopkins, the pair struggled for days to coax brain
cells in cats to respond to images of dark and light spots. Becoming
increasingly frustrated, they waved their arms, jumped around, and, in a
moment of levity, displayed images of glamorous women from magazines.
Then, as they shifted a slide in the opthalmoscope, a cell in the cat’s
visual cortex suddenly started to fire. The edge of the slide had cast a
straight, dark line on the animal’s retina. “It was what the cell
wanted, and it wanted it, moreover, in just one narrow range of
orientations,” Dr. Hubel said in his Nobel lecture.
They studied the cell for nine hours, and then, Dr. Wiesel recalled, ran down the hall screaming with joy.
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