組織碎化超音波（Histotripsy 字源解釋，俗稱「碎化刀」）已在台灣取得衛生福利部食品藥物管理署（TFDA）核准上市，並由台大醫院與台北榮總正式導入臨床應用。

 組織碎化超音波（Histotripsy，俗稱「碎化刀」）已在台灣取得衛生福利部食品藥物管理署（TFDA）核准上市，並由台大醫院與台北榮總正式導入臨床應用。 [1, 2]

治療原理與特色

無創免切口：利用高強度聚焦超音波產生的氣泡效應（Cavitation），以機械力量在體外直接將體內腫瘤震碎並液化，完全不需手術切口、穿刺或放射線。
保護關鍵結構：屬於非熱能消融技術，能避免傳統電燒（RFA）或微波（MWA）產生的熱傷害，完整保留鄰近的大血管與膽管。
快速與恢復快：單次消融時間約10分鐘，術後病人隔天即可出院。 [1, 2, 3, 4]

台灣臨床進展與應用現況

台大醫院：創下全球臨床導入最快紀錄，累積超過80例臨床試驗與治療經驗，並與美商合作成立亞太唯一的「癌症碎化消融訓練中心」。
台北榮民總醫院：獲公益信託捐贈引進設備，規劃打造亞太區組織碎化術無創治療觀摩示範中心。
適應症與收費：目前台灣核准主要應用於肝臟腫瘤（原發性肝癌、膽道癌及肝轉移）。臨床上主要提供自費選擇（單次療程約新台幣50萬元），並積極拓展至胰臟癌、腎臟癌等其他固態腫瘤試驗。 [1, 2, 3, 4]

如果您想進一步了解，請問您希望知道：

• 哪些具體條件與限制適合評估此治療？
• 台大醫院或台北榮總的就醫掛號與諮詢管道？

Histotripsy is a non-invasive medical procedure that uses focused sound waves from ultrasound to break down and liquefy diseased soft tissue, such as liver tumors, without surgery. [1, 2, 3]

The word breaks down into two parts: "histo," meaning soft tissue, and "tripsy," meaning breaking down. [1]

How Histotripsy Works

Acoustic Cavitation: Focused high-intensity ultrasound pulses pass through the skin to hit a precise target.
Bubble Clouds: The sound waves create micro-bubbles inside the targeted tissue that rapidly expand and collapse.
Mechanical Destruction: This rapid movement acts like a microscopic mechanical force that tears apart cell walls without using heat, radiation, or chemicals.
Natural Cleanup: The body naturally absorbs and flushes out the resulting liquid cell debris over time. [1, 2, 3, 4]

Key Benefits

Non-invasive: Requires no cuts, incisions, or needles.
No Heat or Radiation: Avoids thermal burns, ionizing radiation, or chemical toxicity.
Spares Healthy Tissue: Protects critical nearby structures like blood vessels and bile ducts.
Preserves Immune Proteins: Leaves antigens intact, which may help the body's immune system recognize and fight remaining cancer cells. [1, 2, 3, 4, 5, 6, 7]

If you'd like, I can share more details on current FDA approvals or how it compares to traditional thermal ablation.